|
KMID : 1007320110170020088
|
|
Journal of the Korean Society of Menopause
2011 Volume.17 No. 2 p.88 ~ p.93
|
|
|
Association between Seasonal Changes in Vitamin D and Bone Mineral Density
|
|
Choi Seung-Hwa
Lee Duk-Joo
Kim Kwang-Min
Kim Bom-Taeck
|
|
|
Abstract
|
|
|
Objectives:Vitamin D deficiency, which causes secondary hyperparathyroidism, is considered to be a major contributor to osteoporosis. Because the serum 25-hydroxyvitamin D (25-OHD) level depend on sun exposure and, varies by season, the level of serum 25-OHD in each season at which vitamin D status can lead to changes in bone mineral density (BMD) is not known.
Methods:A total of 2,878 women who underwent periodic health examinations at Ajou University Hospital were included in this study. We measured the serum 25-OHD concentrations using radioimmunoassay and BMDs using dual energy x-ray absorptiometry (DXA). The differences in serum 25-OHD levels among groups as a function of age, season, and BMD were tested by one-way ANOVA.
Results: The serum 25-OHD level was not different based on age, but by season, with higher levels in the summer and autumn than in the winter and spring. However, the 25-OHD level did not have a significant relationship with BMD in any season.
Conclusion:The serum 25-OHD level represents vitamin D status at the time of testing, which is not associated with long-term changes in BMD. When the 25-OHD levels are used to make clinical decisions related to the treatment of osteoporosis, careful interpretation is required.
|
|
|
KEYWORD
|
|
|
Bone mineral density, Seasonal variation, Vitamin D
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|